Can unused vCenter database indexes be removed?

I searched the forum and haven't seen this discussed. We are seeing that many indexes on all of our vCenter databases are apparently unused. The indexes have 300-plus million writes (in some cases) but no reads. This seems like a waste of space and an unneeded overhead on the MS SQL server. Can those indexes be removed? vCenter 5.0. MS SQL Server 2008-R2. Thanks in advance!

Examples:

Index:VPXI_VM_RESOURCE_GROUP_ID     Writes=324812477      Reads=0

Index:VPXI_VM_IP_ADDRESS                         Writes=319506727      Reads=0