I don't think you will have problems if the hosts can reach the vCenter, and if vCenter is not reacheable (or crash), this blog post talks about it: Distributed vSwitches and vCenter outage, what's the deal?
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I don't think you will have problems if the hosts can reach the vCenter, and if vCenter is not reacheable (or crash), this blog post talks about it: Distributed vSwitches and vCenter outage, what's the deal?